Job Information
The Children's Hospital of Philadelphia Research Post-Doc Fellow - Hematology - Chou Laboratory in Philadelphia, Pennsylvania
Reference #: 1010454 SHIFT:Day (United States of America)
A Brief Overview Assume responsibility for an on-going, innovative research project as a Postdoctoral Fellow at CHOP. Our postdoc experience will broaden your skillset, scientific background, and research capabilities.
About the Laboratory The postdoctoral fellow (postdoc) will have a terminal degree PhD, MD, DVM, etc. and will, under the direction/guidance of a mentor (principal investigator), assume responsibility for a specific, on-going research project. The position is in the laboratory of Dr. Stella Chou, a Principal Investigator in the Hematology Research Division. Her research focuses on pediatric blood diseases, mechanisms of normal and pathologic hematopoietic development, and the study of vitro generation of red blood cells from induced pluripotent stem cells (iPSCs) for transfusion medicine.
The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group. Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.
Research foci include: Study and enhance in vitro generation of red blood cells from induced pluripotent stem cells (iPSCs) for transfusion medicine Study and enhance in vitro generation of red blood cells from induced pluripotent stem cells (iPSCs) for transfusion medicine Identifying novel methods to expand pluripotent stem cell derived hematopoietic progenitors. Adaption of next generation sequencing technology to improve red cell matching and prevent alloimmunization in patients with sickle cell disease. Understanding how transcription factor GATA1 controls normal erythro-megakaryocytic development and how GATA1 mutations cooperate with genes on chromosome 21 to cause transient myeloproliferative disease and acute megakaryocytic leukemia in patients with Down syndrome. Disruption of candidate chromosome 21 genes using CRISPR/Cas9 technology in pluripotent stem cells to examine their role in the blood abnormalities and predisposition to leukemia associated with Down syndrome.
The Chou laboratory is looking for candidates with a general molecular biology background and tissue culture experience. A background in hematopoiesis and/or experience with CRISPR technology or human primary, ESC, or iPSC culture would be a plus
JOB SPECIFIC STANDARDS: Conduct independent scholarly research and develop new methods and protocols Participate in project planning, recording and evaluation of data Acquire technical, lab management and grant writing skills Participate in seminars, lectures, poster sessions and presentation at national meetings Supervise junior lab members Assist with other research projects
CHOP's Commitment to Diversity, Equity, and Inclusion CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.
We strongly encourage all candidates f diverse backgrounds and lived experiences to apply.
Responsibilities * Participate in project planning, recording, and evaluation of data. * Conduct independent scholarly research, developing new methods and protocols under the guidance of a mentor (principal investigator). * Acquire technical, lab management, and grant writing skills. * Participate in seminars, lectures, poster sessions, national presentations, and professional workshops. * Supervise junior lab members. * Assist with other research projects as needed. Education Qualifications Doctorate (required)
Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.